1. Ibotenic Acid is the principal toxin found in many mushroom species. Cells metabolize this product to another active derivative chemical called Muscimol. Both of these toxins act as excitatory amino acids by mimicking the natural transmitters, glutamic acid and aspartic acid, on neurons in the central nervous system. These toxins may also cause selective death of neurons sensitive to these excitatory amino acids. Ibotenic Acid is a potent glutamate agonist, which has been used to potentiate anesthesia, and to inhibit tremor and emesis. It has also been used to suppress enzymatic activities. When injected into rat brain, it was shown to suppress choline acetyltransferase activity. Seven days after injection, enzyme levels had decreased 60%; after 3 months activity had returned to normal. It is also reported to be an insecticidal agent.
Created: 2019-07-27 13:18:19 EDT (-0400)
Last modified: 2019-08-20 17:37:33 EDT (-0400)