Glossary Term: Amatoxins

1. Amatoxins make up at least ten toxic compounds found in several genera of poisonous mushrooms, most notably Amanita phalloides and several other members of the genus Amanita, as well as some species in Conocybe, Galerina and Lepiota.
2. Amatoxins are cyclic octapeptides that inhibit RNA polymerase II and lead to hepatocyte necrosis as well as renal tubular injury. This can cause nausea, vomiting, cell necrosis, and severe gastroenteritis after ingestion of a mushroom possessing one or more of these chemicals. Species include Amanita virosa (Destroying Angel), Amanita verna (Fool’s Mushroom), and Galerina marginata.

The ten compounds currently known are:

α-Amanitin
β-Amanitin
γ-Amanitin
ε-Amanitin
δ-Amanitin
Amanullin
Amanullinic acid
Amaninamide
Amanin
Proamanullin

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Created: 2019-07-27 13:16:01 MST (-0700)
Last modified: 2019-08-19 12:34:42 MST (-0700)